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Extreme Fatigue, Running


*: represents trainees under my supervision. #: review papers.

*Le Mat F, Géry M, *Besson T, Ferdynus C, *Bouscaren N, Millet GY. Running endurance in women compared to men: retrospective analysis of matched real-world big data. Sports Med 53(4): 917-926, 2023.

Trama R, Blache Y, Hintzy F, Rossi J, Millet GY, Hautier C. Does neuromuscular fatigue generated by trail running modify foot impact and soft-tissue vibrations? Eur J Sports Sci 23(7): 1155-1163, 2023.

*Sabater Pastor F, Tomazin K, Verney J, Féasson L, Millet GP, Millet GY. VO2max and velocity at VO2max play a role in ultradistance trail running performance. Int J Sports Physiol Perform 18(3): 300-305, 2023.

*Besson T, *Sabater Pastor F, Varesco G, *Berthet M, *Kennouche D, Dandrieux PE, Rossi J, Millet GY. Elite vs experienced male and female trail runners: comparing running economy, biomechanics, strength and power. J Strength Cond Res 37(1): 181-186, 2023.

*Perrin TP, Rossi J, Kerhervé HA, Millet GY. Increasing shoe longitudinal bending stiffness is not beneficial to reduce energy cost during graded running. Int J Sports Physiol Perform 18(2): 209-212, 2023.

*Sabater Pastor F, *Faricier R, *Metra M, Murias JM, *Brownstein CG, Millet GYChanges in cost of locomotion are higher after endurance cycling than running when matched for intensity and duration. Med Sci Sports Exerc 55(3): 389-397, 2023.

*Perrin TP, Morio CYM, *Besson T, Kerhervé HA, Millet GY, J. Rossi J. Comparison of skin and shoe marker placement on metatarsophalangeal joint kinematics and kinetics during running. J Biomech 146: 111410, 2023.

Fouré A, *Besson T, Stauffer E, Skinner S, Féasson L, Connes P, Hautier C, Millet GY. Sex-related differences and effects of short and long trail running races on resting muscle-tendon mechanical properties. Scand J Med Sci Sports 32(10): 1477-1492, 2022.

*Khassetarash A, *Baggaley M, *Vernillo G, Millet GY, Edwards WB. The repeated bout effect influences lower-extremity biomechanics during a 30-min downhill run. Eur J Sports Sci 23(4): 510-519, 2023.

*Brownstein CG, *Metra M, *Sabater Pastor F, *Faricier R, Millet GY. Disparate mechanisms of fatigability in response to prolonged running versus cycling of matched intensity and duration. Med Sci Sports Exerc 54(5): 872-882, 2022.

*Sabater Pastor F, *Besson T, *Berthet M, Varesco G, *Kennouche D, Dandrieux PE, Rossi J, Millet GY. Elite road vs. trail runners: comparing economy, biomechanics, strength, and power. J Strength Cond Res 37(1): 181-186, 2023.

*Besson T, Macchi R, Rossi J, Morio C, Kunimasa Y, Nicol C, Vercruyssen F, Millet GY. Sex differences in endurance running. Sports Med 52(6): 1235-1257, 2022.

Lloria-Varella J, *Besson T, Varesco G, Espeit L, *Kennouche D, Delattre N, Millet GY, Morio C, Rossi, J. Running pattern changes after a 38-km trail running race: does shoe fatigue play a role? Footwear Science 14:3, 185-197, 2022.

Coudy-Gandilhon C, Gueugneau M, Chambon C, Taillandier D, Combaret L, Polge C, Millet GY, Féasson L, Béchet D. A single bout of ultra-endurance exercise reveals early signs of muscle aging in master athletes, Int J Mol Sci 23(7): 3713, 2022.

*Sabater Pastor F, *Besson T, Millet GY. Determining factors of trail running performance of various distances. Int J Sports Physiol Perform 17(6): 844-851, 2022.

Alcantara RS, Edwards WB, Millet GY, Grabowski AM. Predicting continuous ground reaction forces from accelerometers during uphill and downhill running: A recurrent neural network solution. PeerJ 10:e12752, 2022.

Nicot F, *Sabater-Pastor F, Samozino P, Millet GY, Rupp T. Effect of ground technicity on cardio-respiratory and biomechanical parameters in uphill trail running. Eur J Sport Sci. 12: 1836-1846, 2022.

*Baggaley M, Derrick TR, *Vernillo G, Millet GY, Edwards WB. Internal tibial forces and moments during graded running. J Biomech Eng, 144(1):011009, 2022.

*Bouscaren N, *Faricier R, Millet GY, Racinais S. Heat acclimatization, cooling strategies, and hydration during an ultra-trail in warm and humid conditions. Nutrients 13(4): 1085, 2021.

*Khassetarash A, *Vernillo G, *Krüger R, Edwards WB, Millet GY.  Neuromuscular, biomechanical, and energetic adjustments following repeated bouts of downhill running. J Sport Health Sci. 11(3): 319-329, 2022.

Koral J, Fanget M, Imbert L, *Besson T, *Kennouche D, *Parent A, Foschia C, Rossi J, Millet GYFatigue measured in dynamic vs. isometric modes after trail running races of various distances. Int J Sports Physiol Perform17(1):67-77, 2022.

Temesi J, *Besson T, *Parent A, *Singh B, Martin V, *Brownstein CG, Espeit L, Rimaud D, *Royer N, Lapole T, Féasson L, Millet GYEffect of race distance on performance fatigability in male trail and ultra-trail runners. Scand J Med Sci Sports, 31(9):1809-1821, 2021.

*Besson T, *Parent A, *Brownstein CG, Espeit L, Lapole T, Martin V, *Royer N, *Rimaud D, *Sabater Pastor F, *Singh B, Varesco G, Rossi J, Temesi J, Millet GYSex differences in neuromuscular fatigue and changes in cost of running after mountain trail races of various distances. Med Sci Sports Exerc 53(11): 2374-2387, 2021.

Skinner S, Nader E, Stauffer E, Robert M, Boisson C, Cibiel A, Foschia C, Féasson L, Robach P, Millet GY, Connes P. Differential impacts of trail and ultra-trail running on cytokine profiles: an observational study. Clin Hemorheol Microcirc, 78(3):301-310, 2021.

#.Tiller NB, Elliott-Sale KJ, Knechtle B, Wilson PB, Roberts JD, Millet GYDo sex-differences in physiology predispose females to success in ultra-endurance sport? Sports Med 51(5): 895-915, 2021.

*Sabater Pastor F, Varesco G, *Besson T, *Koral J, Féasson L, Millet GYDegradation of energy cost with fatigue induced by trail running: effect of distance. Eur J Appl Physiol 21(6):1665-1675, 2021.

Espeit L, *Brownstein C, *Royer N, *Besson T, Martin V, Millet GY, Lapole T. Central fatigue aetiology in prolonged trail running races. Exp Physiol 106: 663–672, 2021.

Marillier M, Rupp T, Bouzat P, Walther G, Millet GY, Robach P, Verges S. Cerebral Haemodynamics and Oxygenation During Whole-Body Exercise Over 5 Days at High Altitude. Exp Physiol 106(1):65-75, 2021.

#.*Brownstein CG, Millet GY, Thomas K. Neuromuscular responses to fatiguing locomotor exercise. Acta Physiol 231(2): e13533, 2021.

Robert M, Stauffer E, Nader E, Skinner S, Boisson C, Cibiel A, Féasson L, Renoux C, Robach P, Joly P, Millet GY, Connes P. Impact of trail running races on blood viscosity and its determinants: effects of distance. Int J Mol Sci 21: 8531, 2020.

*Khassetarash A, *Vernillo G, *Martinez A, *Baggaley M, Giandolini M, Horvais N, Millet GY, Edwards WB.   Biomechanics of Graded Running: Part II – Joint Kinetics and Kinematics. Scand J Med Sci Sports 30(9):1642-1654, 2020.

*Vernillo G, *Martinez A, *Baggaley M, *Khassetarash A, Giandolini M, Horvais N, Edwards WB, Millet GY Biomechanics of Graded Running: Part I – Stride Parameters, External Forces, Muscle Activations, and their Interactions with Speed. Scand J Med Sci Sports 30(9):1632-1641, 2020.

Matta GG, Bossi AH, Millet GY, Lima P, de Lima JP, Hopker JG. Influence of a slow-start on overall performance and running kinematics during 6-h ultramarathon races. Eur J Sport Sci 20(3): 347-356, 2020.

*Mira J, *Floreani M, *Savoldelli A, *Amery K, *Koral J, *Oranchuk D, Messonnier L, Rupp T, Millet GYNeuromuscular fatigue in hypoxia revisited Med Sci Sports Exerc 52(9): 1888-1899, 2020.

*Besson T, Rossi J, Marechal M, Leroux Mallouf T , Doutreleau S, Vergès S, Millet GYNeuromuscular fatigue and recovery after a single vs multi-stage mountain race of the same distance. Med Sci Sports Exerc 52(8): 1691-1698, 2020.  

*Vernillo G, *Aguiar M, *Salvodelli A, *Martinez A, Giandolini M, Horvais N, Edwards WB, Millet GY. Regular changes in foot strike pattern during prolonged downhill running do not influence neuromuscular, energetics, or biomechanical parameters. Eur J Sport Sci 20(4): 495-504, 2020.

*Azevedo R, Cruz R, Couto P, Silva-Cavalcante MD, Boari D, Lima-Silva AE, Millet GY, Bertuzzi R. Characterization of performance fatigability during a self-paced exercise. J Appl Physiol, 127 (3) : 838-846, 2019.

#.Millet GY, Martin V, *Temesi J. The Role of the Nervous System in Neuromuscular Fatigue Induced by Ultra-Endurance Exercise. Appl Physiol Nutr Metab 43 (11) : 1151-1157, 2018.

*Martin T, *Arnal PJ, Hoffman MD, Millet GYSleep habits and strategies in ultramarathon runners . PLOS One 13 (5) : e0194705, 2018.

Gergelé L, Venet F, Ravelojaona M, Morel J, Féasson L, Hayman J, Villars-Méchin A, Millet GY, Monneret G. Mountain ultra-marathon finishers exhibit marked immune alterations similar to those of severe trauma patients. Intensive Care Med 44 (3) : 382-383, 2018.

*Vernillo G, Millet GP, Millet GY. Does the running economy really increase after ultra-marathons? Front Physiol 8 :783, 2017.

*Giandolini M, Horvais N, Rossi J, Millet GY, Morin JB, Samozino P.  Effects of the foot strike pattern on muscle activity and neuromuscular fatigue in downhill trail running. Scand J Med Sci Sports 27(8) : 809-819, 2017.

*Tomazin K, Morin JB, Millet GY. Etiology of Neuromuscular Fatigue After Repeated Sprints Depends on Exercise Modality. Int J Sports Physiol Perform 12 (7) :878-885, 2017.

#.*Vernillo G, *Giandolini M, Edwards WB, Morin JB, Samozino P, Horvais N, Millet GY. Biomechanics and Physiology of Uphill and Downhill Running. Sports Med 47 (4) : 615-629, 2017.

*Jubeau M, *Rupp T, Perrey S, Wuyam B, Millet GY , Verges S. Neuromuscular fatigue during prolonged exercise in hypoxia. Med Sci Sports Exerc 49 (3) : 430-439, 2017.

#.Giandolini M, *Vernillo G, Edwards WB, Morin JB, Samozino P, Horvais N, Millet GY. Fatigue Associated with Uphill and Downhill Running. Eur J Appl Physiol 116 (10): 1859-73, 2016.

*Giandolini M, *Temesi J, Gimenez P, *Arnal PJ, Martin V, Rupp T, Morin JB, Samozino P. Millet GYEffect of the Fatigue Induced by a 110-km Ultramarathon on Tibial Impact Acceleration and Lower Leg Kinematics . PLOS One 11 (3) : e0151687, 2016.

*Giandolini M, Horvais N, Rossi J, Millet GY, Morin JB, Samozino P. Acute and delayed peripheral and central neuromuscular alterations induced by a short and intense downhill trail run. Scand J Med Sci Sports 26 (11) :1321-33, 2016.

Degache F, Morin JB, Oehen L, Guex K, Giardini G, Schena F, Millet GY, Millet GP. Running mechanics during the World’s most challenging mountain ultra-marathon. Int J Sports Physiol Perform, 11 (5) : 608-14, 2016.

*Kerherve H, Millet GY, Solomon C. The dynamics of speed selection and psycho-physiological load during a mountain ultramarathon. PLOS One 10 (12) : e0145482, 2015.

*Temesi J, *Arnal PJ, *Rupp T, Féasson L, Cartier R, Gergelé L, Verges S, Martin V, Millet GYAre females more resistant to extreme neuromuscular fatigue? Med Sci Sports Exerc 47 (7) :1372-1382, 2015.

*Temesi J, Rupp T, Martin V, *Arnal PJ, Féasson L, Verges S, Millet GYCentral Fatigue Assessed by Transcranial Magnetic Stimulation in Ultratrail Running. Med Sci Sports Exerc, 46 (6) :1166-1175, 2014.  This article was chosen for an editorial comment.

*Jubeau M, *Rupp T, Perrey S, *Temesi J, Wuyam B, Levy P, Verges S, Millet GYChanges in cortical voluntary activation during prolonged cycling exercise. PLOS One 9 (2) : e89157, 2014.

Robach P, Vincent L, Boisson RC, Lundby C, Duthil E, Moutereau S, Michel N, Gergelé L, Féasson L, Millet GYHemolysis induced by an extreme mountain ultra-marathon is not associated with a decrease in total red blood cell volume. Scand J Med Sci Sports, 24 (1) : 18-27, 2014.

*Temesi J, *Arnal PJ, Davranche K, Bonnefoy R, Verges S, Millet GYDoes central fatigue explain reduced cycling after complete sleep deprivation? Med Sci Sports Exerc 45 (12) : 2243-2253, 2013. This article was chosen for an editorial comment.

Saugy J, Place N, Millet GY, Degache F, Schena F, Millet GP. Alterations of neuromuscular function after the World most challenging mountain ultramarathon. PLOS One: 8 (6) : e65596, 2013.

Gimenez P, *Kerhervé H, Messonnier L, Féasson L, Millet GYChanges in the energy cost of running during a 24-h treadmill exercise. Med Sci Sports Exerc 45 (9) :1807-1813, 2013.

Degache F, Fourchet F, Morin JB, Guex K, Millet GP, *Tomazin K, Millet GYChanges in running mechanics and spring–mass behaviour induced by a 5-hour hilly running bout. J Sports Sci 31 (3) : 299-304, 2013.

Millet GP, Millet GY. Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress. BMC Med 10 :77, 2012.

Grenier JG, Millet GY, Peyrot N, Samozino P, Messonnier L, Morin JB. Effects of heavy load carriage for extreme duration on neuromuscular function and locomotion: a military-based study. PLOS One 7 (8) : e43586, 2012.

Millet GY, Hoffman MD, Morin JB. Viewpoint: Sacrificing economy to improve running performance – a reality in the ultramarathon? J Appl Physiol, 113 (3) : 507-509, 2012.

Jamart C, Francaux M, Millet GY, Deldicque L, Frere D, Féasson L. Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running. J Appl Physiol, 112 (9) : 1529-1537, 2012.

Millet GY, *Muthalib M, Jubeau M, Laursen P, Nosaka K. Severe hypoxia affects exercise performance independently of afferent feedback and peripheral fatigue. J Appl Physiol, 112 (8) : 1335-1344, 2012.

Morin JB, *Tomazin K, Samozino P, Edouard P, Millet GYHigh-intensity sprint fatigue does not alter constant-submaximal velocity running mechanics and spring-mass behavior. Eur J Appl Physiol 112 (4) :1419-1428, 2012.

Fourchet F, Millet GP, *Tomazin K, Guex K, Nosaka K, Edouard P, Degache F, Millet GYEffects of a 5-h hilly running on ankle plantar and dorsal flexor force and fatigability. Eur J Appl Physiol 112 (7) : 2645-2652, 2012.

#.Verges S, *Rupp T, *Jubeau M, Wuyam B, Estève F, Perrey S, Millet GYCerebral perturbations during exercise in hypoxia. Am J Physiol Regulatory Integrative Comp. Physiol 302 (8) : R903-R916, 2012.

*Tomazin K, Morin JB, Strojnik V, Pedpecan A, Millet GYFatigue after short (100-m), medium (200-m) and long (400-m) treadmill sprints. Eur J Appl Physiol 112 (3) :1027-1036, 2012.

Millet GY, *Tomazin K, Verges S, Vincent C, Bonnefoy R, Boisson RC, Gergelé L, Bonnefoy R, Féasson L, Martin V. Neuromuscular consequences of an extreme mountain ultra-marathon. PLOS One 6 (2) : e17059, 2011.

Morin JB, *Tomazin K, Edouard P and Millet GYChanges in running mechanics and spring-mass behavior induced by a mountain ultra-marathon race. J Biomech 44 (6) : 1104-1107, 2011.

#.Millet GYCan neuromuscular fatigue explain running strategies and performance in ultra-marathons? The flush model. Sports Med 41 (6) : 489-506, 2011.

Morin JB, Samozino P, Millet GYChanges in running kinematics, kinetics, and spring-mass behavior over a 24-h run. Med Sci Sports Exerc 43 (5) : 829-836, 2011.

Nicolas M, *Banizette M Millet GYStress and recovery states during a 24 h ultra-marathon race: a one month follow-up study. Psychol Sports Exerc 12 : 368-374, 2011.

Millet GY, *Banfi JC, *Kerhervé H, Morin JB, Vincent L, Estrade C, Geyssant A, Féasson L. Physiological and biological factors associated with a 24 h treadmill ultramarathon performance. Scand J Med Sci Sports 21 (1) : 54-61, 2011.

Martin V, *Kerhervé H, Messonnier L, *Banfi JC, Geyssant A, Bonnefoy R, Féasson L, Millet GYCentral and peripheral contributions to neuromuscular fatigue induced by a 24-hour treadmill run. J Appl Physiol 10:1224-1233, 2010.

Millet GY, Morin JB, Degache F, Edouard P, Féasson L, Verney J, Oullion R. Running from Paris to Beijing: biomechanical and physiological consequences. Eur J Appl Physiol 10: 731-738, 2009.

Millet GY, *Aubert D, Favier FB, Busso T, Benoît H. Effect of acute hypoxia on central fatigue during repeated isometric leg contractions. Scand J Med Sci Sports. 19 (5) : 695-702, 2009.

Place N, Lepers R, *Deley G, Millet GYTime course of neuromuscular alterations during a prolonged running exercise. Med Sci Sports Exerc 36 : 1347-1356, 2004.

#.Millet GY, Lepers R. Alterations of neuromuscular function after prolonged running, cycling and skiing exercises. Sports Med 34 : 105-116, 2004.

*Martin V, Millet GY, *Lattier G, *Perrod L. Effects of recovery modes after knee extensor muscles eccentric contractions. Med Sci Sports Exerc 36 : 1907-1915, 2004.

Millet GY, *Martin V, Maffiuletti NA, Martin A. Neuromuscular fatigue after a ski skating marathon. Can J Appl Physiol 28 : 434-445, 2003.

Millet GY, *Martin V, *Lattier G, Ballay Y. Mechanisms contributing to knee extensor strength loss after prolonged running exercise. J Appl Physiol 94 : 193-198, 2003.

Millet GY, Lepers R, Maffiuletti NA, Babault N, *Martin V, *Lattier G. Alterations of neuromuscular function after an ultramarathon. J Appl Physiol 92 : 486-492, 2002.

Lepers R, Maffiuletti NA, Rochette L, Brugniaux J, Millet GYNeuromuscular fatigue during a long-duration cycling exercise. J Appl Physiol 92 : 1487-1493, 2002.