Menu Fermer

John Temesi


Senior Lecturer in Sport and Exercise Science, Faculty of Health and Life Sciences, Northumbria University (United Kingdom)

01/2014 – 07/2016 – Calgary, Canada

Understanding the cause of fatigue & exhaustion in whole-body exercises in normal & extreme conditions (Pincipal Supervisor)


Dr John Temesi is a senior lecturer at Northumbria University in Newcastle upon Tyne, UK. He completed his PhD at Université Jean Monnet in 2013 under the supervision of Professor Guillaume Millet  and Dr Samuel Vergès before spending 2.5 years as a postdoctoral fellow at the University of Calgary, also under Guillaume’s supervision. After a further 2 years as an Associate Assistant Professor at University of Calgary, John moved to the UK. John has published more than 35 peer-reviewed journal articles and more than 20 conference abstracts. His research is in the area of exercise physiology and exercise neurophysiology, especially as it relates to fatigue, and spans from clinical to athletic populations and ranges from fundamental mechanistic research to applied research that can be translated to real-world settings. Over the years, John and Guillaume have worked on many projects together that have focused on fatigue in different populations and different environments. They have also conducted extensive work on improving how fatigue is assessed to better understand how fatigue manifests and impacts performance and activities of daily living. John and Guillaume continue to collaborate on a number of areas including fatigue in ultra-endurance exercise and cancer-related fatigue.

Main results of the work we have done together

Fatigue in extreme environments (mostly ultra-endurance):

  • An important component of the central fatigue observed during ultra-trail running races is supraspinal in nature.
  • Females exhibited less fatigue than males after an ultra-trail running race, specifically, females had less global knee extensor fatigue and less peripheral fatigue in the plantar flexors.
  • The observed physical performance decrement observed after one night of sleep deprivation is not attributable to changes in maximal strength or neuromuscular function and fatigue. This suggests that fatigue during ultra-endurance exercise (of sufficient duration for there to be sleep deprivation) is not due to sleep deprivation during the exercise bout.

Main publications associated with this work

John Temesi, Pierrick J Arnal, Thomas Rupp, Léonard Féasson, Régine Cartier, Laurent Gergelé, Samuel Verges, Vincent Martin, Guillaume Y Millet. Are females more resistant to extreme neuromuscular fatigue? Med Sci Sports Exerc. 2015 Jul[invited commentary]

John Temesi, Thomas Rupp, Vincent Martin, Pierrick J Arnal, Léonard Féasson, Samuel Verges, Guillaume Y Millet. Central fatigue assessed by transcranial magnetic stimulation in ultra-endurance trail runningMed Sci Sports Exerc. 2014 Jun.

John Temesi, Pierrick J Arnal, Karen Davranche, Régis Bonnefoy, Patrick Levy, Samuel Verges, Guillaume Y Millet. Does central fatigue explain reduced cycling after complete sleep deprivation? Med Sci Sports Exerc. 2013 Dec.

Fatigue and exercise interventions in clinical populations with muscular dystrophy and cancer:

  • In patients with fascioscapulohumeral muscular dystrophy (FSHD), a six month home based exercise programme consisting of strength, high-intensity interval and low-intensity aerobic exercise performed on an exercise bike was deemed to be safe while improving muscle strength and endurance,  muscle cross-sectional area, motor function, perceived fatigue and cardiorespiratory fitness.
  • The work on mechanisms of cancer-related fatigue and the effects of tailored exercise interventions on cancer-related fatigue is ongoing and publications from this work are forthcoming.

Main publications associated with this work

Landry-Cyrille Bankolé, Guillaume Y Millet, John Temesi, Damien Bachasson, Marion Ravelojaona, Bernard Wuyam, Samuel Verges, Elodie Ponsot, Jean-Christophe Antoine, Fawzi Kadi, Léonard Féasson. Safety and efficacy of a six-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy: a randomized controlled trialMedicine (Baltimore). 2016 Aug.

Rosie Twomey, Tristan Martin, John Temesi, S Nicole Culos-Reed, Guillaume Y Millet. Tailored exercise interventions to reduce fatigue in cancer survivors: study protocol of a randomized controlled trial. BMC Cancer. 2018 Jul 24.

Brownstein C, Twomey R, Temesi J, Wrightson J, Martin T, Medysky M, Culos-Reed N, Millet GY. 2021. Physiological and psychosocial correlates of cancer-related fatigue. J Cancer Surviv.

Brownstein CG, Twomey R, Temesi J, Medysky ME, Culos-Reed SN, Millet GY. Mechanisms of Neuromuscular Fatigability in People with Cancer-related Fatigue. Med Sci Sports Exerc. 2022

Methodological research performed in order to either improve assessment of neuromuscular fatigue and function (e.g. new methods or tests) or to evaluate methods of assessment (i.e. comparison of methods, reliability):

  • Anew cycling ergometer with force sensors was developed that enables both dynamic (i.e. cycling) exercise and isometric neuromuscular evaluations to be performed such that neuromuscular evaluations can be performed within one second of exercise cessation. This led to the adaptation of an incremental isometric test to cycling for more real-world application.
  • Stimulus-response curves performed at submaximal contraction intensity were determined to be appropriate for determining transcranial magnetic stimulation intensity to evaluate voluntary activation.
  • The Quadriceps Intermittent Fatigue (QIF) test is reliable in persons with fascioscapulohumeral muscular dystrophy (FSHD) and a limitation of using femoral nerve magnetic stimulation is that in some persons the stimulus is not sufficiently strong.

Main publications associated with this work

Douglas Doyle-Baker, John Temesi, Mary E Medysky, Robert J Holash, Guillaume Y Millet. An innovative ergometer to measure neuromuscular fatigue immediately after cycling. Med Sci Sports Exerc. 2018 Feb.

John Temesi, Mathieu Gruet, Thomas Rupp, Samuel Verges, Guillaume Y Millet. Resting and active motor thresholds versus stimulus-response curves to determine transcranial magnetic stimulation intensity in quadriceps femoris. J NeuroEng Rehab. 2014 Mar 21.

Damien Bachasson, John Temesi, Landry-Cyrille Bankolé, Emmeline Lagrange, Boutte C, Millet GY, Vergès S, Levy P, Féasson L, Wuyam B. (2014). Assessment of quadriceps strength, endurance and fatigue in FSHD and CMT: benefits and limits of femoral nerve magnetic stimulation. Clin Neurophysiol 125: 396-405.